Nisin is a polycyclic antibacterial peptide obtained by fermentation of Lactococcus lactis subsp. lactis. It is composed of 34 amino acids and belongs to the lantibiotic family, known for its unique ability to inhibit the growth of heat-resistant Gram-positive bacteria and bacterial spores.
Recognized as GRAS by the FDA and approved by WHO, FAO, EU, and China, Nisin is one of the most effective natural preservatives for a wide range of food applications. It is non-toxic, biodegradable, and suitable for clean-label formulations.
Key Features and Benefits:
Natural origin: Produced via microbial fermentation; accepted in natural and organic foods.
Broad-spectrum inhibition: Effective against Listeria, Clostridium, Bacillus, and Staphylococcus.
Heat stability: Maintains antimicrobial activity during pasteurization and sterilization.
pH-resilient: Most effective in acidic environments (pH < 5), ideal for sauces and canned foods.
Safe and biodegradable: No accumulation in the body or environment; suitable for long-term use.
Applications:
Processed Meats: Prevents spoilage and enhances safety in ham, sausages, and deli products.
Dairy Products: Extends shelf life of cheese, milk drinks, and yogurt.
Canned & Acidic Foods: Used in canned vegetables, soups, and sauces to prevent spore germination.
Beverages & Dressings: Applied in acidic fruit juices or salad dressings to prevent microbial growth.
Bakery Fillings & Prepared Meals: Used in fillings and ready-to-eat foods that require extended shelf life.
Usage & Dosage:
Recommended dosage is 200–1000 IU/g, depending on regulatory limits and food type. Nisin works best in acidic conditions (pH 3.5–4.5) and can be used alone or in synergy with other preservatives like natamycin or ε-polylysine.
Packaging & Storage:
Available in 500g, 1kg, and 5kg vacuum-sealed foil bags. Store in a dry, cool place below 25°C, protected from light and humidity. Shelf life is 24 months under recommended conditions.